Toothpaste has had three major developments in the history of its use. The first was the addition of fluoride which has significantly reduced the amount of childhood cavities. Secondly, the addition of pyrophosphate which reduces the amount of calculus. Finally there was triclosan, added in order to combat gum disease. New developments in research are aimed at targeting the chemical attraction between the acquired pellicle and bacterial plaque to reduce the collection of plaque biofilm.